Endocrine Abstracts

Both hyper- and hypothyroidism show reduced spontaneous and GHRH-stimulated GH secretion. Although impaired GHRH secretion and activity as well as reduced GH pituitary synthesis have been reported in these pathological conditions, a definitive description of the underlying pathophysiological mechanisms have not been provided yet. Ghrelin elicits a potent GH-releasing effect partially mediated by a functional somatostatin antagonism and a synergic interaction with GHRH. Moreove...

Background: Percutaneous laser ablation (LA) is a therapeutic procedure used for the reduction of benign thyroid nodules. After LA a 50% nodule reduction was observed by most authors. However, eligibility criteria for LA based on long term efficacy have not been established.Methods: Seventy-two patients (51 women and 21 men) with benign cold thyroid solitary nodules or a dominant nodule within a normo-functioning multinodular goiter underwent thermal Nd:...

Despite the common clinical opinion that thyrotoxicosis is associated with quantitative and qualitative sleep alterations, at present, an objective evaluation of sleep quality and quantity in this clinical condition has never been performed so far. Based on this foregoing, in order to perform a qualitative and quantitative description of sleep in this clinical condition, we enrolled 6 normal-weighted patients suffering from naïve overt hyperthyroidism due to Basedow Disea...